Physiological functions of biliary lipid secretion
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منابع مشابه
The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump.
Human bile salt export pump (BSEP) mutations underlie progressive familial intrahepatic cholestasis type 2 (PFIC2). In the PFIC2 animal model, Bsep(-/-) mice, biliary secretion of bile salts (BS) is decreased, but that of phospholipids (PL) and cholesterol (CH) is increased. Under physiological conditions, the biliary secretion of PL and CH is positively related ("coupled") to that of BS. We ai...
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ZENIYA, M., AND A. REUBEN. Triton WR-1339-induced changes in serum lipids and biliary lipid secretion. Am. J. Physiol. 254 (Gastrointest. Liver Physiol. 17): G346-G354, 1988.-Biliary lipid secretion rates were measured in fed rats after an intravenous injection of Triton WR-1339 (TWR, 60 mg/lOO g body wt), an agent that inhibits lipoprotein removal from the circulation. Serum triglyceride, phos...
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Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro. To explore a role for PC-TP in the hepatocellular trafficking of biliary phosphatidylcholines, we characterized biliary lipid secretion using Pctp(-/-) and wild-type littermate control mice with C57BL/6J and F...
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The bile fluid contains various lipids that are secreted at the canalicular membrane of hepatocytes. As the secretion mechanism is still a matter of debate and a direct experimental observation of the secretion process is not possible so far, we used a mathematical model to simulate the extraction of the major bile lipids cholesterol, phosphatidylcholine and sphingomyelin from the outer leaflet...
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تاریخ انتشار 2017